EXPERIENCES

1996–Present Chemical Abstracts Service Columbus , OH
System Engineer

Responsibility highlights: Chemical Abstracts Service flagship software, SciFinder, algorithm design and development. Requirements analysis and reviews.

• SciFinder Smart Substructure Searching Algorithm Design, SciFinder Reaction Searching Algorithm Design and Testing.
• Analyze Organic Chemistry Patents and Journals.
• Chinese Patents Analyses for Marpat Database

1994–1996 Agouron Pharmaceuticals
San Diego , CA
Research Scientist

Responsibility highlights: biochem activity elv

• New Drug Discovery in the Area of HIV and Rhinovirus.using protein X-ray crystallography X-ray technique to determine the three-dimensional atomic structures of target proteins and the drugs that bind to them.
• Conduct Organic Syntheses and Characterizations using state-of-art instrumentation as two-dimentional NMR and Nuclerau magentic resournce.

1991–1994 Novartis Pharmaceuticals
Summit , NJ
Associate Scientist

• Conduct Organic Syntheses and Characterizations

EDUCATION & TRAINING

• 1997–2000 Franklin University,
  Columbus, OH
  B.S. in Computer Science
  ( Magna Cum Laude )
  President list
• 1989–1991 Purdue University
  Indianapolis , IN
  M.S. in Organic Chemistry
• 1979–1983 Tianjin University
  Tianjin , China
  B.S. in Chemistry
  All A Student for Six Semesters

PUBLICATIONS
Webber, Stephen E.; Okano, Koji; Little, Thomas L.; Reich, Siegfried H.; Xin, Yue ; Fuhrman, Shella A.; Matthews, David A.; Love, Robert A.; Hendrickson, Thomas F.; Patick, Amy K.; Meador, James W., III; Ferre, Rose Ann; Brown, Edward L.; Ford, Clifford E.; Binford, Susan L.; Worland, Stephen T. Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease: Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P1 Glutamine Isosteric Replacements . J. Med. Chem . (1998), 41(15), 2786-2805. CODEN: JMCMAR ISSN:0022-2623. CAN 129:189651 AN 1998:446846

Xin, Yue ; Hu, Ying; Zeldin, Martel; Fife , Wilmer K. Copolymerization of hydrophilic and hydrophobic 1-alkyl-4-vinylpyridinium monomers . Macromolecules (1993), 26(17), 4670-4. CODEN: MAMOBX ISSN:0024-9297. CAN 119:139862 AN 1993:539862

Fife , Wilmer K.; Zeldin, Martel; Xin, Yue ; Parish, Carol. Copolymerization in self-organized systems . Polym. Prepr . (Am. Chem. Soc., Div. Polym. Chem.) (1991), 32(1), 579-80. CODEN: ACPPAY ISSN:0032-3934. CAN 115:208622 AN 1991:608622

Zeldin, Martel; Fife , Wilmer K.; Tian, Cheng Xian; Xin, Yue . Siloxanes with 1-oxypyridin-3-yl groups. Part 6. Synthesis of copolymers and application as transacylation catalysts . British Polym. J . (1989), 21(6), 481-6. CODEN: BPOJAB ISSN:0007-1641. CAN 112:139962 AN 1990:139962

Fife , Wilmer K.; Xin, Yue . Inverse phase-transfer catalysis: probing its mechanism with competitive transacylation . J. Am. Chem. Soc . (1987), 109(4), 1278-9. CODEN: JACSAT ISSN:0002-7863. CAN 106:84099 AN 1987:84099